Correlation of urinary markers versus blood biomarkers in osteoporotic fractures

Introduction: Little has been published on the biochemical changes
 that can cause or a predisposing factor for osteoporotic fracture. The aim of the study is to assess whether there is any correlation of fracture to the level of serum parathyroid hormone, serum vitamin D and urinary n telopeptide. Materials and Methods: Prospective study done at Sri Ramachandra Institute of Medical Science, Chennai between October 2015 to October 2017.The Inclusion criteria were persons above 50 years of age and the patients above 50 who comes within 24 hrs following trivial fall fractures. All patients who participated in the study underwent Dexa scan for diagnosis of osteoporosis, urinary n telopeptide and biochemical tests like serum calcium, serum phosphate, Alkaline phosphatase, 25-hydroxy vitamin D and serum parathyroid. The patients were divided into two groups. Group I had patients without fracture and Group II had patients who had osteoporotic fractures. Results: We had nearly twenty one pertrochantric fractures patients followed by sixteen distal radius patients. The mean value of urinary n telopeptide was 55.7 in group I and 186.39 in group II. The mean value of serum PTH was 69.5 in group I and 72.9 in group II. Conclusion: Urinary marker correlates well with the osteoporotic fracture and will be a better diagnostic tool than the blood biomarkers of osteoporosis.