FORMULATION, OPTIMIZATION AND EVALUATION COLON TARGATED DRUG DELIVERY SYSTEM FOR ORNIADAZOLE

The colon is a site where both local and systemic delivery of drugs can take place. The present investigation concerns with formulation and evaluation of Colon Targeted dip coated tablets of Ornidazole by using HPMCK4 M, Xanthan gum polymers .Initially core tablets were prepared and then coated by using Eudragit S100 as a enteric coating polymer with the help of Isopropyl alcohol, acetone (1:1) by deep coating. Optimization of colon targeted tablet of Ornidazole was carried out by using design expert software considering combination of HPMC K 4 M & Xanthan gum as independent variable & Time for 25% Drug release (hrs), Drug Release at 12 hrs as a dependent variable. All the formulations FB1 to FB9 were evaluated for the physicochemical parameters and were subjected to in vitro drug release studies. The tablets were passed all the tests. Among all the formulations FB5 formulation was found to be optimized as it was retarded the drug release up to 12 hours and showed maximum of 91.57% drug release. The results of the present study have demonstrated that developed colon targeted coated tablet were promising vehicle for preventing rapid hydrolysis in gastric environment and improving oral bioavailability of ornidazole for the treatment of disease of colon region. Key Words: Colon targeted, Ornidazole, Optimization, Eudragit S 100, Coating.