Active Ingredients and Their Toxicity of Several Forest Plant Species Indigenous from North Sulawesi Potential as Efficacious Medicine

Utilization of germplasms as medical sources presents a form of traditional wisdom adopted by a particular community which is identicalwithahereditarylegacy.Thispaperdealsdescriptivelywithethnobotanyaspectsof NorthSulawesicommunity(Minahasa, Mongondow and Sangihe tribes) in utilizing natural bioresources from several forest plant species as traditional cancer-curing treatment, which was further proved scientifically through the identification of active ingredients contents and their efficacious toxicity using Brine Shrimp Lethality Test (BSLT) method. Scrutiny results revealed that the local community in North Sulawesi province hasprevalentlyutilizedparticularportions(e.g.wood,bark,andleaves)of 14forestplantspeciesforcancercureandotherdesease.The herbal extract from the bark of lawang ( Bl) was identified containing alkaloids, while flavonoids was detected in the extract from consecutively lingkube ( Steud) leaves, yantan ( Dc) leaves, ketapang ( L) bark, manumpang ( Jacq) bark, tanduk rusa stems, kayu gimto ( sp) roots, rumput balsam ( ) roots, and cakar kucing ( L) roots. The leaves of luhu( L)andkuhung-kuhung( Dc)containingsteroidsandtannins.Asmanyas9outof 12n-butanolextractsaffordedtoxicityefficacyagainstlarvaeof LeachwhichwasconfirmedthroughtheLC value, i.e. bellow 1000 ppm. Further, the least LC value was achieved using the petroleum eter-extract kuhung-kuhung (crotalaria striata dc) leaves, i.e. 68,33 ppm, whereby that value approached the effectiveness standard for bioactive compounds to fight against thecancercell,whichwasbasedontheUnitedStatesNationalCancerInstitute.