Stir bar sorptive extraction as a sample preparation technique for chromatographic analysis: An overview

Sample preparation is an important step in chemical analysis. The present article gives an overview about the Stir bar sorptive extraction (SBSE) as a technique for sample preparation for chromatographic analysis. Stir bar extraction, desorption steps and optimization of the extraction conditions like pH, extraction time, addition of an inert salt, addition of an organic modifier and stirring speed have been discussed. Extraction mechanism, advantages, disadvantages and some applications in water, environmental, pharmaceutical and food analysis have been also discussed. The application of SBSE can be considered as an attractive alternative to classical extraction methods by reducing the consumption of and exposure to the solvent, disposal cost, and extraction time.