CORRELATION BETWEEN INTERLEUKIN 17 AND TRANSFORMING GROWTH FACTOR BETA WITH HABITUAL ABORTION IN WOMEN INFECTED WITH CYTOMEGALOVIRUS

Background: Interleukin 17 and transforming growth factor beta (TGF-β) are known with their effect on immune cells, and play a key role in the pathogenesis of some cell-mediated diseases, such as autoimmune diseases and cancer. Recurrent pregnancy loss (RPL) is a challenging field in generative medicine, the etiology of RPL is still not fully understood, and the knowledge regarding guides-based diagnostic and treatment are limited. Aim of study: The aim of this study was to investigate the the role of Interleukin 17 (IL17) and transforming growth factor beta (TGFβ) to CMV immunoglobulin in RPL in Iraqi patients infected with Cytomegalovirus (CMV), and to correlate them with RPL status, compared to the healthy control. Patients and methods: This study included 88 pregnant women, 37 women represented the healthy control, where no history of recurrent abortion. 24 patients were with two or more recurrent abortion, and 27 patients had a single abortion. The sera levels of IL17, TGFβ, and anti-CMV IgG, IgM were measured in blood patients by the enzyme-linked immunosorbent assay (ELISA). Results: The results revealed high levels of anti-CMV IgG in RPL patients compared to the healthy control (83.3%, 96.3% and 56.8% respectively; (p<0.001). While no significant difference was noted in levels of IgM anti-CMV, IL17 and TGFβ among the studied groups (p<0.001). Conclusion: There is a strong correlation between elevated anti-CMV IgG and RPL. However, IgM anti-CMV IL17 and TGFβ were correlated directly with in RSL patients compared with healthy control.