Theoretical evaluation of medicinal properties for some of N-aryl-3-hydroxypyridine-4-ones derivative compounds

Journal: Iranian Chemical Communication (Vol.2, No. 2)

Publication Date: 2014-04-01

Authors : Mohsen Oftadeh; Lotfollah Saghaie; Shahla Pirialam;

Page : 82-92

Keywords : Hydroxypridinone; partition coefficient; chelating agent; density functional theory;

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Abstract

Today, the bidentate ligands 3-hydroxypyridin-4-ones (HPOs) as orally active iron chelating agents have been demonstrated to possess potential for treatment of some human diseases such as iron-overload in thalassaemic patients and malaria. In this research, a series of HPOs with different substitutes and position were theoretically invest

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Theoretical evaluation of medicinal properties for some of N-aryl-3-hydroxypyridine-4-ones derivative compounds

Abstract

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