A Study on Genes Identification with Expression Levels Related to Breast Cancer Prognosis Using Data Mining Techniques

The study of identifying genes more correlated with the prognosis of breast cancer, we used data mining techniques to study the gene expression values of breast cancer patients with known clinical outcome. Focus of our work was the creation of a classification model to be used in the clinical practice to support therapy prescription. We randomly subdivided a gene expression dataset of 96 samples into a training set to learn the model and a test set to validate the model and assess its performance. We evaluated several learning algorithms in their not weighted and weighted form, which we defined to take into account the different clinical importance of false positive and false negative classifications. Based on our results, these last, especially when used in their combined form, appear to provide better results.