Prostaglandins and its Types
Journal: PharmaTutor (Vol.2, No. 5)Publication Date: 2014-05-01
Authors : SR Silpa;
Page : 31-37
Keywords : Prostaglandins; COX; inflammatory response;
Abstract
Prostaglandins are potent bioactive lipid messengers synthesized from arachidonic acid mediated by enzyme COX. Prostaglandins (PGs) play a key role in the initiation of the inflammatory response. Their biosynthesis is significantly increased in inflamed tissue, and they contribute to the development of the cardinal signs of acute inflammation. Although the proinflammatory properties of individual PGs during the acute inflammatory response are well established, their role in the resolution of inflammation is more controversial.
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Last modified: 2014-05-14 17:30:41