A SIX-MONTHLY DESCRIPTIVE OBSERVATIONAL RESEARCH ON IN-VITRO EFFICACY OF CIPROFLOXACIN, COTRIMOXAZOLE AND NITROFURANTOIN AGAINST NUMEROUS URINARY ISOLATES

Background: Young adults face the issue of urinary tract infections as a common disease. Because of the increased use of the fluoroquinolones, empirical therapy in the case of an uncomplicated infection of the urinary in the target age group has also become controversial. Our research was also aimed at the nitrofurantoin efficacy, cotrimoxazole and ciprofloxacin (trimethoprim-sulphamethaxazol); these are orally used drugs available in common. Material & Methods: Our descriptive research was held in Services Hospital, Lahore (Microbiology Department) in the time span of January – June, 2016. We included a total of 270 isolates of urinary tract infection selected from outdoor and indoor respectively 132 and 138; culturing of the specimens was also carried out in the time span of the research. We identified the isolates through conventional techniques with the help of API – 10 S. We also assessed all the isolated for ciprofloxacin, nitrofurantoin and cotrimoxazole (trimethoprim-sulphamethaxazol) along with related common antibiotics which are also used for the urinary pathogens. Results: In the total sample of the research dominant isolated was E. Coli which was cultured in the 158 cases (58.51%), after that the Klebsiella pneumonia in 48 cases (17.77%) & enterococcus spp respectively in 16 cases (5.92%). The sensitive percentage in the outdoor cases (132) was observed as nitrofurantoin (92.4%), ciprofloxacin (47.1%) and cotrimoxazole (62.1%); whereas in the indoor isolates (138) the respective sensitivity was observed as 84.0%, 34.7% and 28.9% respectively. Conclusion: The effectiveness of the Nitrofurantoin is outdoor and indoor isolates is useful in the empirical urinary tract infection which is not complicated. Keywords: Nitrofurantoin, Cotrimoxazole, Ciprofloxacin, Trimethoprim-sulphamethaxazol, Urinary Tract Infections and Urine.