CROSS SECTIONAL STUDY TO KNOW THE CORRELATION OF NEPHROPATHY WITH LDL DYSLIPIDEMIA IN DIABETIC PATIENTS

Objective: The aim of this study was to determine the correlation and cause-and-effect relationship between LDL cholesterol and nephropathy in the diabetic population. Design: cross-sectional analytical study. Place and Duration: The study was performed in the Nephrology Department of Bahawal Victoria Hospital, Bahawalpur for the period of two years from June 2015 to June 2017. Patients and Methods: A total of 500 adult diabetic patients were selected for this study. Serum LDL creatinine, cholesterol, microalbumin and urine macroalbumin were measured using the standard laboratory method. LDL was labeled as 100mg / dL dyslipidemia and defined as microalbuminuria or macroalbuminuria as nephropathy. Findings: Of the 500 patients, 320 (71.3%) were dyslipidemia and 180 (28.7%) were nephropathy. Dyslipidemic patients (LDL> 100) showed slightly higher levels of serum creatinine with a mean creatinine level of 1.022 ± 0.74 mg / dl compared to those with a mean creatinine level of 1.004 ± 0.63 mg / dl. However, subjects with nephropathy showed a significant serum LDL cholesterol level of 125.7 ± 44.8 mg / dL compared to those without nephropathy, with an average LDL of 114 ± 39 mg / dL. The Spearman correlation was highly significant for the causal relationship between serum LDL and nephropathy (p <0.001). Conclusion: The observed data indicate that the highest levels of LDL are associated with higher creatinine levels, nephropathy development and progression. Control of LDL dyslipidemia is one of the effective strategies for controlling diabetes to prevent diabetic nephropathy. Key words: Diabetes, dyslipidemia, LDL cholesterol, microalbuminuria, nephropathy.