A SIX-MONTH EXPERIENCE OF PROSPECTIVE RESEARCH ON THE PENTAZOCINE, BUPRENORPHINE AND TRAMADOL EFFECT ON OPIOID ALLERGIC ASA I & II PATIENTS UNDERGOING CAESARIAN SECTION

Objective: Evaluation of the effects of Buprenorphine, Pentazocine and Tramadol on Respiration. Study design: This study is prospective. Place and duration of study: The study at hand was carried out in the month of July to December 2017. Intensive Care Unit (ICU) of Mayo Hospital, Lahore was the place of this study. Patients and methods: Total 60 patients related to ASA-I&II grades undergoing elective cesarean section were selected. Their age groups range from 18-35 years. Patients allergic to Opioids and those who were having severe systematic diseases not falling in ASA 1 or 2, were not considered in the study. Non-probability convenience sampling technique was used. Selected patients were divided into 03 groups. Twenty patients were allocated to every group. Endotracheal general anesthesia was administered to all the patients. Following operation, injection Buprenorphine 0.5mg IM was received by Group "A", Pentazocine 30mg IM was received by Group "B" and Tramadol 100mg IM was received by Group "C". After giving analgesia, its effects on arterial blood gases, tidal volume, minute volume and respiratory rate, were observed after half an hour, an hour, two hours and four hours. Repetition of the doses was performed eight-hourly. Results: After thirty minutes, respiratory rate and minute volume were seen to be decreasing in case of Buprenorphine. Effect of Pentazocine was dissimilar as it decreased minute volume in five minutes and decrease of respiratory rate was in thirty minutes. However, Tramadol has neither affected respiratory rate nor minute volume. Buprenorphine and Pentazocine decreased PaO2 within thirty minutes. The rise of PaCO2 was seen after one hour with Buprenorphine, whereas Pentazocine raised the same within five minutes. No changes were seen in arterial blood gas values with Tramadol. Conclusion: Opioids possess a respiratory depressant effect which is observable from thirty to sixty minutes of IM administration. In contrary, in equal-potent doses, respiratory depression is not caused by Tramadol being a non-opioid. Keywords: Parenteral, Buprenorphine, Pentazocine, Tramadol, Blood Gas Analysis, Respiration, Analgesia, Buprenorphine, Blood Gas Analysis, Buprenorphine and Recovery room.