Role of Insulin Resistance in Males with Early Androgenetic Alopecia

Early androgentic alopecia (EAA): is an androgen related disorder. It could be a clinical marker of insulin resistance and hyperinsulinaemia in men with EAA <35years. Insulin resistance (IR): is a condition in which the body produces insulin but does not use it properly. We aimed in this study to evaluate the role of IR in males with EAA. Subject and methods: This study was performed on a total of 30 male patients with EAA aged between 18-50 years Vs 30 age matched healthy subjects as a control group. All subjects were subjected to: full history taking, dermatologic examination, grading of Androgenetic alopecia. Measurement of (IR), serum cholesterol, TG, serum insulin, Systolic blood pressure (SBP), Body Mass Index (BMI) and waist circumference, fasting plasma glucose (FPG), LDL, HDL, and Diastolic Blood Pressure(DBP), Result; There was significant increase in (IR), serum cholesterol, (TG), serum insulin, (SBP), (BMI) and waist circumference in patient group in comparison with control group while no significant difference regarding (FPG), (LDL), (HDL) and (DBP) in both groups. There was significant increase in IR in progress with grading of androgenetic alopecia. IR significantly increased with age in patient group. Neither duration nor family history of EAA had significant association with IR. Smoking had significant impact on IR in both groups. Conclusion and Recommendation: Strong association between IR EAA and its grading, dyslipidemia, hyperinsulinaemia and hyperglycemia should be excluded in males with EAA should.