Malignant Degeneration of Oral Condyloma Acuminatum

Background: Condyloma acuminatum is considered to be a benign lesion of oral cavity; in comparison to its anogenital counterpart which carries a significant malignant potential. Oral condyloma acuminatum lesions have not been reported in literature to undergo malignant change. Methods: A 47 year old patient presented with a rapidly progressive proliferative mass in oral cavity infiltrating the skin. He was operated earlier for excision of tumour at same site which was diagnosed as condyloma acuminatum. Results: This case study shows that there may be a potential risk of malignant degeneration for oral condyloma acuminatum to oral squamous cell carcinoma in long term. Conclusion: An oral condyloma acuminatum patient need to be followed up regularly for long time to detect potential malignant transformation and larger prospective study is required to establish its malignancy potential and/or annual transformation rate.