Metastatic Prostate Cancer Initially Presenting as Supraclavicular Lymphadenopathy

Prostate cancer is one of the most common neoplasm occurring in men worldwide. It can present with diverse clinicopathological features that can cause a diagnostic conundrum. We report one such rare and an unusual manifestation of this cancer in a 40-year-old male who initially presented with supraclavicular lymph node enlargement. There are very few cases in the literature which have described supraclavicular lymphadenopathy as the initial presentation of metastatic prostate cancer in men younger than 45 years of age. These patients rarely undergo digital rectal examination or serum prostate-specific antigen level measurement as part of their initial investigations. A high index of suspicion is necessary to make the diagnosis of prostate cancer in such atypical cases.