Regulation of Adiponectin and its Receptors by Endogenous and Exogenous Factors

Adiponectin is a hormone-derived adipose tissue. There is two form of adiponectin as low molecular weight (LMW) and high molecular weight (HMW). It has important role in energy homeostasis and is related to disease such as insulin resistant and obesity. In fact, the fluctuant in its serum level is affective in abnormality of energy homeostasis. Here, we reviewed the effect of both endogenous and exogenous factors on regulation of adiponectin. Based on our review, adiponectin and its receptors can consider as special therapeutic targets to treat diabetes, obesity and cardiovascular disease.