The Effects of Melatonin in Bone Healing

Melatonin, an endogenous hormone, regularly is produced in pineal gland. Suprachiasmatic nucleus and the light/dark cycle controls melatonin function. Melatonin doesn't act upon specific target tissue; it reaches all organs and tissues and enters all intra cellular structures like mitochondria and nucleus. Melatonin has an important effect on physiological processes of body including regulation of blood pressure, circadian rhythms, ovarian function, seasonal reproduction, and immune function. The general ef fects of melatonin in bone health were proposed by many researchers during the last years. First experiments studied the influence of the pineal gland on level of serum calcium. It has been saw that inhibition the melatonin biosynthesis by exposure of youn g rats to the fluorescent light decrease the concentration of calcium in the serum. The effects of melatonin on bone healing were investigated by scientists, and they observed which melatonin protects the bone from fracture. Studies have showed which melat onin has an influential role on bone - healing because of its regulation of bone cells, antioxidant properties, and promotion of angiogenesis actions. Scientists have been show that melatonin has aninfluential role in bone healing process due to its regulati on of bone cells, antioxidant properties, and promotion of angiogenesis actions.