Preclinical Pharmacology and Toxicology: an Important Aspect in Drug Discovery
Journal: Advances in Clinical Toxicology (Vol.1, No. 1)Publication Date: 2016-05-25
Authors : Rupa G;
Page : 1-3
Keywords : Pharmacology; Toxicology; Preclinical; Drug discovery; Translational studies; Hits; Lead;
Abstract
It is imperative to have safety and efficacy evaluation completed for a test compound before proceeding to translate for clinical trials. Preclinical pharmacology and toxicological studies play an essential role for providing particulars to design clinical studies to determine whether the test compound is as efficacious and safe in humans as it was observed in animal studies. Study performed in preclinical setting includes determination of safety, efficacy, tolerability and toxicity for the test compound. These studies help to propose a safe and efficacious startup dose for human studies. Furthermore, it won't be wrong to state that without these preclinical pharmacological and toxicological studies it is not possible to strategize and design clinical trial in humans.
Other Latest Articles
- Chromophoric Dissolved Organic Matter (CDOM) as an Indicator for Studying Carbon Cycle in the Northern Bay of Bengal
- Law Worship: The Latest “Idol Worship”- American Totalitarianism, the Death of Medicine and Why “The Law” is Contemptible--Gulag America
- Sphincter of Oddi Dysfunction: A Survey of Current Practice in USA
- Effect of Designed Guidelines on Nurses′ Performance to Prevent Preterm Infants′ Hypothermia
- Monitoring of Nitrification Process Occurrence in Aquatic Systems Linked to Water Quality Index
Last modified: 2018-05-26 14:55:41