The Implication of Molecular Diagnosis and Good Laboratory Practices in the Reduction of Laboratory Animal Disease: An Approach for Management of Healthcare in Animal Facilities

Diagnosis of diseases is concerned with the identification of accurate and precise causal factors and the direct and indirect relationship between host and organisms. Infectious disease diagnosis in laboratory animals includes traditional techniques like direct examination, culture along with immunological assessments. However, these traditional techniques have limitations of sensitivity; time consumption, and accuracy, thereby molecular approaches can be a modern choice to examine the health of laboratory animals. Modern molecular diagnostic techniques, explore nucleic acids based typing characteristics for identifying the health status and pathogen intensities. Laboratory testing on animal models required expertise with extensive statistical analysis, quality control. Despite considerable improvement, an error arises from laboratory experiments. Controlled and continued quality improvement strategy via regulatory guidelines like good laboratory practices (GLP) would serve as the best tool for reduction of errors and monitoring of laboratory animal health. GLP implication in laboratory animal health care management is a landmark tool for reducing the incidences of disease events. This quality system includes planning, monitoring, recording, archiving and reporting components. This planned system contributes in the generation of precise and accurate results of the experiments conducted on laboratory animals. The present study describes the role of GLP and molecular approach in the management of laboratory animal health.