Effect of Ocimum sanctum Against Alloxan Induced Diabetes and Biochemical Alteration in Rats

Diabetes is a group of metabolic disease and associated with impaired glucose metabolism, resulting from defect in insulin secretion, action and both. The present study was undertaken to evaluate the insulin secretion and anti-oxidative potential of Ocimum sanctum extract in diabetic rats. The results showed that extensive oxidative stress is generated in tissues of diabetic rats, increased the production of blood glucose, total cholesterol, triglyceride, creatinine, SGOT, SGPT, ALP and bilirubin, oxidative stress and decreased insulin secretion. Herbal medicines are widely used because of their effectiveness, no side effect and low cost. Treatment with aqueous suspension of Ocimum sanctum decrease serum glucose, total cholesterol, triglyceride, creatinine, SGOT, SGPT, ALP and bilirubin level in diabetic group as compared with control group. Aqueous suspension of Ocimum sanctum showed antidiabetic activity against diabetes.