Effect of Hydrochlorothiazide on Pharmacodynamics and Pharmacokinetics of Telmisartan in Human Patient Volunteers

The present study was aimed to evaluate the effect of hydrochlorthiazide on pharmacodynamics and pharmacokinetics of Telmisartan using human patients. A total of 118 hypertensive patients were included in this study. The reduction in the blood pressure in patients receiving the Telmisartan alone and in patients receiving the both Telmisartan and hydrochlorthiazide was estimated. The pharmacokinetic parameters also estimated using the plasma levels of Telmisartan in both group of patients. The findings of present investigation have concluded that the efficiency of Telmisartan along with the Hydrochlorothiazide was high when compared to that of Telmisartan alone, and preliminary pharmacokinetic data also revealed that there were no interactions with the usage of combination of drugs. Pharmacodynamics response, i.e., decrease of blood pressure was high with the usage of combination of Telmisartan along with hydrochlorothiazide, which was a combined pharmacological action exerted by both drugs individually.