Aqueous Suspension of Ocimum sanctum on Alloxan Induced Diabetic Rats through Lipid Peroxidation and Biochemical Parameters in Blood

Diabetes is a disease associated with glucose metabolism resulting from defect in insulin secretion, action or both. Hyperglycemia was induced oxidative stress and causes of complication in diabetes. The present study was aimed to investigate the effect of Ocimum sanctum on alloxan induced diabetic rats, insulin secretion, metabolic disorder and oxidative stress in diabetic rats. The present study includes blood glucose, total cholesterol, triglyceride, uric acid, creatinine, insulin, c-peptide, and lipid peroxidation level and tissue histology in all groups. Diabetic rats increase the level of blood glucose, total cholesterol, triglyceride, uric acid, creatinine, MDA and 4HNE and decrease the level of insulin, c-peptide and change tissue architecture of pancreas as compared to respective control group. Diabetic rats treated with aqueous suspension of Ocimum sanctum improve the secretion of insulin, repaired metabolic disorder, reduce oxidative stress and prevented all these observed abnormalities. Aqueous suspension of Ocimum sanctum showed antidiabetic properties.