Possible Effects of Paraoxonase 1 Q192r Polymorphism on Serum Paraoxonase Activities of a Group of Type 2 Diabetes Mellitus Patients

Paraoxonase (PON) 1 is an antioxidant enzyme a member of PON family held accountable for the protection against several diseases, exposures and xenobiotics like paraoxon. It has been shown that genetic and phenotypic changes in PON1 concentration evoke some diseases such as Diabetes Mellitus (DM). The recent studies indicated in both Type 1 and Type 2 DM patients; serum PON1 activity and concentrations are diminished. In the light of this information, we carried out this study to evaluate lipid profiles and possible relationship between PON1 activity and PON1 Q192R polymorphism in a group of Turkish Type 2 diabetic patients. Due to our experimental data, the PON activity of the patients with minor RR variant is significantly higher than patients with QQ and QR variants (p<0.01). To conclude, we observed PON1 192RR genotypes are relevant to enhanced PON activity than the other variants. This situation may be interpreted as more protective to lipid peroxidation.