Optimization and Formulation Design with In-Vitro Evaluation of Fast Disintegrating Tablets Containing Candesartan Solid Dispersions
Journal: Open Access Journal of Pharmaceutical Research (Vol.1, No. 6)Publication Date: 2017-08-30
Authors : Gurunath S Baswaraj KN; Patil PA;
Page : 1-11
Keywords : Factorial Design; Candesartan; Crospovidone; Camphor; Dissolution Rate; Sublimation;
Abstract
The aim of this study was to assess the effects of processing parameters on the release of solid dispersion formulation from a fast dissolving tablet dosage form. Graphical and mathematical analysis such as the response surface methodology (RSM) and multiple response optimizations utilizing the polynomial equation were used to search for the optimal formulation and to quantify the effect of each formulation variables. To optimize the influence of superdisintegrant (crospovidone) and subliming agent (camphor) on the prediction of disintegration time (Y1), percentage friability (Y2) and wetting time (Y3), a two factor, three levels (32) full factorial design was used. Results of multiple regression analysis revealed that an optimum concentration of camphor and a higher percentage of crospovidone are required for obtaining rapidly disintegrating tablets. The optimized formulation was subsequently subjected to a short-term accelerated stability study. Processing parameters have shown a profound effect on the release of solid dispersion formulations from its hydrophilic carrier. The observed results of Y1, Y2 and Y3 coincided well with the predictions in the RSM optimization technique, indicating it was quite useful for optimizing pharmaceutical formulation. The release kinetic of drug from fast dissolving tablets followed the first-order release pattern. Experimental values obtained from the optimized formulations were in close to the predicted values, thus confirming the validity of the generated mathematical model. In conclusion, this study demonstrated the potential of statistical experimental design in elucidating the effects of the formulation variables on the rapidly disintegrating tablets containing solid dispersion of a hydrophobic drug.
Other Latest Articles
- FEMINISTIC ISSUES IN ALICE WALKERS THE COLOUR PURPLE
- LOW BONE MINERAL DENSITY IS ASSOCIATED WITH SMOKING AND BODY MASS INDEX
- Screening of Endophytic Fungal Secondary Metabolites from Garcinia kola and Cola nitida for Antioxidant Properties
- ALLOGRAFTS AND ITS SAFETY IN PERIODONTAL REGENERATIVE THERAPY
- Microbial Quality Evaluation of Zobo Drink Sold i n University of Maiduguri
Last modified: 2018-05-26 17:52:07