Dengue and Zika Virus Infection; Immunopathogenetic Likeness?

Dengue and Zika viruses are closely related. They have the same mode of transmission, are structurally similar and sequential infections do occur. These observations have led to the hypothesis that these viruses share a common pathogenesis. Both cellular and humoral immunity play a role in Dengue virus infection. Research is being conducted to determine if the same immune mechanisms are responsible for spread and pathogenesis of Zika virus as well.