Relationships between Alteration in Leptin and Glucose Homeostasis

Glucose homeostasis is firmly controlled by insulin and also by leptin adipocytokines. Theses hormones act significantly on regulating adiposity and food intake in human beings. Leptin effects on the insulin-glucose homeostasis, controlling of body weight (obesity) and adiposity. Leptin secretion and effects are controlled centrally in the hypothalamus and superficially in the muscles, pancreas and liver that regulate the insulin-glucose metabolism via diminishing insulinemia, glycemia, and insulin resistance. Major understanding of the functional effects of leptin on relationship between insulinglucose homeostasis will enhance the leptin-based targeted therapies against diabetes and other metabolic syndromes (insulin resistance disorders). In study, summarize the regulatory roles between leptin and glucose homeostasis in diabetes.