ADRENAL CORTICAL CARCINOMA- A CASE REPORT

Adrenal cortical carcinoma is a rare endocrine neoplasm with a world wide incidence of two per million population.There is a bimodal age distribution. Tumours may be functional or non functional depending on whether they produce cortisol , androgens , aldosterone or estrogen . The etiology of adrenal cortical carcinoma is unknown, although recent studies documenting chromosomal abnormalities and alterations in growth factor production have provided insight into possible mechanisms of molecular pthogenesis . Associated with Li-Fraumani syndrome, MEN-1, Beckwith Wiedman syndrome and carney complex. Complete surgical resection is the curative therapy for localized adrenal cortical carcinoma. 65yrs old female patient presented with CO lower abdominal pain , abdominal swelling ,loss of weight loss of appetite.USG and CT showed Large, lobulated, heterogenous space occupying lesion in the region of left adrenal gland measuring 12 x8 x 7.5 cms and central necrosis is noted. We did open adrenalectomy . Histopathology report came as adrenal cortical carcinoma. In the past 5 years only two cases are reported in Rajiv Gandhi Government General Hospital, Chennai.