INFANTILE ALEXANDER DISEASE- A CASE REPORT

Alexander disease, a rare and fatal disorder of the central nervous system, most commonly affects infants and young children but can also occur in older children and sometimes adults. Megalencephaly, demyelinization and multiple Rosenthal fibers (1) characterize it. Specific magnetic resonance imaging (MRI) findings and genetic investigations are necessary to diagnose the disorder (2). Here we report a rare case of Alexander disease in an 8 months old infant, who presented with developmental regression, megalancephaly and seizures with leukodystrophic findings in the frontal white matter bilaterally on magnetic resonance imaging, suggestive of Alexander disease