Development And Evaluation Of Gastroretentive Floating Tablet Of Rosuvastatin

Gastroretentive floating matrix tablets of the antihyperlipidemic drug Rosuvastatin were successfully prepared using hydrophilic polymers like HPMC K4M and Carbapol. From the Preformulation studies for drug excipients compatibility it was observed that there was no compatibility problem with the excipients used in the study. The Formulated tablets gave satisfactory results for various physicochemical evaluation studies like Weight variation Floating lag time Content uniformity Total floating time Mucoadhesion time mucoadhesive strength and in vitro drug release and shows a floating time of around 12 hrs.