Goblet Cell Carcinoid of Appendix: Report of Two Cases and Review of Controversial Aspects

Goblet cell Carcinoid is a rare type of appendix tumor that constitutes 14% of malignant appendix neoplasms. Management of these lesions is a challenge; there are many controversial points and, until now, no consensus has been achieved. They are stemmed from pluripotential cells placed on inte stinal crypt base, as a result, they are hybrid tumors with mucinous and neuroendocrine differentia tion. This peculiar feature becomes them into a heterogeneous group that requires special attention. According to WHO, they are considered a subtype of mixed adenoneuroendocrine carcinoma, under neuroendocrine category. Tang described three hystological ty pes, group A, B and C, based on presence of goblet cells, signet ring cells and carcinoma component, as long as architecture and pattern of distribution. Although, it is generally accepted that their behavior is intermediate between Carcinoid and adenocarc inoma, prognosis is related to Tang's groups and TNM (7th edition). Recently, some studies have pointed that goblet cell Carcinoid is a peritoneal disease, and treatment should include hyperthermic intraoperative peritoneal chemotherapy, for this purpose, patients should be referred to centers of excellence. We report two cases of goblet cell Carcinoid, group A and B, and review controversial aspects