A Pig Model for the Histological Analysis of Adipocytes after Co - injections of Autologous Fat with Fillers

Background: Currently, the rise of micro - plastic injections has become a significant trend in aesthetic medicine and safety issues among many materials such as botulinum toxin, hyaluronic acid, and injects able poly - L - lactic acid, have been discus sed. However, there is not much discussion about the safety of these materials and autologous fat grafting. Therefore, we conducted this study in an attempt to investigate undiscovered interactions between autologous fat and botulinum toxin, hyaluronic aci d or inject able poly - L - lactic acid. Materials and methods: The Lee - Sung pig model was used to analyze histological changes of Adipocytes after various injections such as mono injection of autologous fat, co - injection of hyaluronic acid with autologous fat , co - injection of poly - L - lactic acid with autologous fat and mono injection of botulinum toxin followed by autologous fat grafting, and to observe interactions between these materials and autologous fat. Results: Fibrosis easily occurred between the trans planted fat cells in the area where muscles were relaxed by botulinum toxin. N o special interaction, but only mild fibrosis was found while hyaluronic acid and autologous fat were co - administered. The inject able poly - L - lactic acid caused granulomatous reactions, but these granulomas had no special histological interaction with transplanted fat cells . Conclusion: The results from our pig model showed that there was no histological interaction between autologous fat and h yaluronic acid/ poly - L - lactic acid, which could be good implications for clinicians.