Whole Parasites as Promising Malaria Vaccines: Previous Efforts and New Developments

Malaria is an important infectious disease in the world that it is the cause of million deaths each year, especially in pregnant woman and child. Different individual preventive strategies have been applied in endemic regions to reduce the rate of infection, but those were not effective totally. Consequently, it seems that development of potent vaccines would be the best solution for blocking the parasite life cycle. According to the non-promising results of sub-unit vaccines for malaria, whole parasite vaccines have been reintroduced to overcome the present obstacles. This review describes the different types of whole parasite malaria vaccines based on their preparation methods.