ASSESSMENT OF PROGNOSTIC BIOMARKERS FOR ORAL TONGUE SQUAMOUS CELL CARCINOMA (SCC)

Introduction: Oral squamous cell carcinoma (OSCC) is the most common malignancy of the head and neck (excluding non-melanoma skin cancer), with more than 300,000 new cases reported annually worldwide. Objectives of the study: The basic aim of the study is to find the some important biomarkers which are useful in the diagnosis and treatment of oral tongue squamous cell carcinoma (SCC). Material and methods: The study was conducted according to the rules and regulations of ethical committee of hospital. The patients who was suffering from oral cancer was selected for this study during the time period of 2016 to 2017. 5.0 ml blood sample was taken from vein. Blood was further processed for the estimation of serum biomarkers i.e Sialic acid, NO, Vita-A, Vit-E and GSH. Results: The data represents that there is a statistical difference among control group and patients. The data shows all the expected prognostic markers which used for the assessment of OSC in humans. The value of GSH and SOD shows that these are the most important biomarkers for the analysis of OSC in humans. Conclusion: According to analysis of data it is concluded that GSH, MDA and SOD are the important diagnostic biomarkers in the assessment of OSSC. Key words: OSSC, GSH, Antioxidants, Cancer