CHEMOPREVENTION OF LUNG CARCINOGENESIS IN STRAIN BALB/C MICE WITH POLYPHENOLS OF MAHKOTA DEWA (PHALERIA MACROCARPA) FROM INDONESIAN HERBAL

Backgroud and objective: Polyphenols of Mahkota Dewa (Phaleria macrocarpa) has potential as anticancer that is expected to inhibit lung carcinogenesis, but it has not been widely studied. This study aims to prove the role of Mahkota Dewa polyphenols to inhibit the progression of lung carcinogenesis development in mice. Methods: The design used in this study is posttest serial control group design with 40 strain Balb/c mice as samples, aged 1-2 weeks, weighted 20-30 g, and in healthy condition. All mice were induced using B(a)P then were randomized into 2 groups: the control group and the 50 mg polyphenols treatment group. The development of lung tumor was observed with tissue surgery at week-8, -17, and -26. The examination of lung carcinogenesis incidence was done using H&E staining. Results: The data were analyzed using Kruskal-Wallis, Mann-Whitney, with significance level of p