A PROSPECTIVE, RANDOMIZED STUDY COMPARING THE ANTIEMETIC EFFECT OF INTRAVENOUS GRANISETRON AND ORAL GABAPENTIN IN PREVENTING POSTOPERATIVE NAUSEA AND VOMITING AFTER MIDDLE EAR SURGERY IN ADULT

Aim: To compare the efficacy of prophylactic intravenous administration of Granisetron 3mg versus Gabapentin 300 mg orally in preventing Postoperative Nausea and Vomiting in patients undergoing middle ear surgeries in adults undergoing general anaesthesia. Materials and methods: 60 ASA 1 and 2 patients between ages of 18 to 60 yrs , who were scheduled for elective middle ear surgeries under general anaesthesia were included in this study. They were randomly assigned to two groups. Group-1 received 3 mg i.v Granisetron 2 minutes prior to induction and Group B received 3 mg oral Gabapentin I hour before induction. In postoperative period , using visual analogue scale the rate of severity of postoperative nausea were assessed. Results: Results were analysed by using Chi- Square test and Fisher extract test. By conventional criteria the association between the intervention groups using visual analogue scale to assess postoperative nausea and vomiting is considered to be statistically insignificant since p > 0.05 as per unpaired t test Conclusion: From this study it is concluded that i.v Granisetron and oral Grabapentin groups have equal anti- emetic effect. There is no significant intraoperative and postoperative haemodynamics as well as side effects.