SYNTHESIS AND CHARACTERIZATION OF MONO/BIS β- LACTAMS BY USING [2+2] CYCLOADDITION REACTION AND STUDY ANTIHYPERGLYCEMIC ACTIVITY

This study is concerned with the synthesis of 3-phenylthio/3 phthalimido mono/bis azetidine-2-one compounds from (phenylthio aceticacid/phthalimido aceticacid with appropriate Schiff's bases using POCl3 and Et3N in CH2Cl2 under N2 atmosphere and characterization of these compounds by IR, UV, Mass, 1H-NMR, 13C-NMR. and study anti hyperglycemic activity for 2, 2'-(1, 1'-(1, 4-phenylene) bis (2-(4-(dimethylamino) phenyl) - 4 ? oxoazetidine- 3, 1-diyl)) diisoindolin-1, 3-dione (3d). used rats (Rattus norvegicus)injected with Alloxan, Alloxane a beta-cytotoxin induces chemical diabetes through damage of insulin secreting cells. test compound (3d) significantly lowered the serum glucose levels indicating their anti-hyperglycemic activity.