NEUROPROTECTIVE EFFICACY OF SWARNA BHASMA ON SLEEP DEPRIVED INDUCED COGNITIVE IMPAIRMENT IN RATS
Journal: Indian Drugs (Vol.55, No. 03)Publication Date: 2018-03-28
Authors : Khan A.Y. Sheikh A. A. Tenpe C. R. Patole A. M. Biyani K. R.;
Page : 43-48
Keywords : ;
- NEUROPROTECTIVE EFFICACY OF SWARNA BHASMA ON SLEEP DEPRIVED INDUCED COGNITIVE IMPAIRMENT IN RATS
- The Quintessential Residents Sleep Sleep Deprived Cognitive Impairment in Residents of a Large Teaching Hospital
- SERUM FETUIN- A LEVEL AND RENAL IMPAIRMENT INDUCED BY OBESITY IN COMPARISON WITH RENAL IMPAIRMENT INDUCED BY GENTAMICIN IN RATS
- Effect of Swarna Bhasma on Memory and Learning in Swiss Albino Mice
- NEUROPROTECTIVE EFFECT OF ROSUVASTATIN ON CA1 & CA3 REGIONS OF HIPPOCAMPUS IN HIGH FAT DIET AND STRESS INDUCED RATS
Abstract
The present investigation was carried out to evaluate neuroprotective efficacy of swarna bhasma on cognitive impairment induced by sleep deprivation in rats. Radial arm maze and elevated plus maze methods were used for behavioural testing in rats. The male albino rats were divided into five experimental groups as normal, sleep deprived control, galantamine and two test groups of swarna bhasma. All the animals except normal were kept on daily 8 to 9 hrs sleep restriction for the induction of cognitive impairment. The cognitive performances were checked on the 7th, 14th and 20th day. Treatment with Swarna bhasma reversed the performances by improved spatial memory, increased correct arm entries, decreased number of errors, time to complete task and decreased in transfer latency. Estimation of biochemical parameters in blood plasma of treated groups with Swarna bhasma showed to be more potent antioxidant and reverts the sleep deprived induced cognitive deficits in rats.
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