NEW ECO-FRIENDLY TITRIMETRIC ANALYSIS OF FRUSEMIDE TABLETS USING MIXED HYDROTROPIC SOLUBILISATION

In the present study, a blend of 15% w/V sodium salicylate, 5% w/V niacinamide, 5% w/V sodium acetate and 5% w/V sodium citrate was prepared to carry out titrimetric estimation of frusemide tablets. The solubility of frusemide in distilled water at room temperature was found to be 0.64 mg/mL. The solubility of frusemide was significant in this mixed hydrotropic blend (21.39 mg/mL) with more than 33 fold enhancement in solubility. The crushed powder of tablets of frusemide was extracted using this blend. The analysis of the drug was done by titrimetric analysis with 0.1M sodium hydroxide solution. Various organic solvents like methanol, chloroform, dimethyl formamide and ethanol have been employed for solubilisation of poorly water soluble drugs to conduct their titrimetric analysis. This proposed method for analysis is recommended because it eliminates the use of toxic solvents and it is a novel, rapid, accurate and reproducible method that is economic as well. Statistical data proved accuracy, precision and reproducibility of the proposed analytical method. The proposed method uses the concept of mixed hydrotropy and provides an alternative method of analysis where the toxicity of solvents can be eliminated.