SOLUBILITY ENHANCEMENT OF OFLOXACIN BY MIXED SOLVENCY APPROACH
Journal: Indian Drugs (Vol.55, No. 06)Publication Date: 2018-06-30
Authors : Gadade D. D. Lohade T. S. Lahoti S. R. Rawat S. S. Maheshwari R. K;
Page : 34-40
Keywords : ;
Abstract
In current study we attempted mixed solvency approach for solubility enhancement of poorly water soluble drug, ofloxacin. Various hydrotropic agents including sodium benzoate, urea, sodium citrate, sodium acetate, niaciniamide, Lignocaine hydrochloride, PEG6000, PEG-400 were evaluated under study for enhancing solubility of drug. Further effect of various blends of these hydrotropic agents on solubility of ofloxacin was studied. Aqueous injection of ofloxacin was prepared and evaluated for its antimicrobial effectiveness and stability. It was found that mixed solvency approach is useful in solubility enhancement of ofloxacin without affecting its antimicrobial properties.
Other Latest Articles
- BOX–BEHNKEN METHOD TO OPTIMIZE LORNOXICAM PRONIOSOMES: PREPARATION, IN VITRO CHARACTERIZATION AND ANALGESIC ACTIVITY
- CHEMICAL CONSTITUENTS AND ESSENTIAL OIL ANALYSIS FROM THE LEAVES OF PIPER BETLE L. VARIETY DESI
- Information Theory, Quark Clusters in Nuclei, and Parton Distributions
- SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL BENZODIAZEPINE CONTAINING BENZOTHIAZEPINE/BENZOXAZEPINE DERIVATIVES AS POTENT ANTICONVULSANT AGENTS
- Економічна ефективність використання трудових ресурсів у сільському господарстві
Last modified: 2018-07-13 20:30:44