Diagnostics of impaired carbon metabolism in patients with ischemic heart disease
Journal: Medicni perspektivi (Vol.23, No. 2)Publication Date: 2018-06-19
Authors : Mankovsky G.B.;
Page : 46-52
Keywords : diabetes mellitus; prediabetes; fasting plasma glucose; glycated hemoglobin; oral glucose tolerance test; ischemic heart disease; coronarography;
Abstract
Aim of the study – to investigate the prevalence of earlier non-diagnosed type 2 diabetes mellitus and prediabetes using different diagnostic approaches in patients with angiographically confirmed ischemic heart disease. Materials and methods. We studied 89 patients with ischemic heart disease, mean age 62+3,6 years. All patients had angiographically confirmed atherosclerotic lesions of coronary arteries. No patient had previously diagnosed diabetes mellitus or hyperglycemia in anamnesis. All patients underwent the detailed examination to reveal hidden diabetes or prediabetes, earlier non-diagnosed: glucose tolerance, fasting plasma glucose, glycated hemoglobin were measured and standard oral glucose tolerance test was performed. Results. Based on the results of fasting plasma glucose and oral glucose tolerance test, diabetes mellitus was diagnosed in 14 (16%) patients studied, elevated glycated hemoglobin suggesting the presence of earlier non-diagnosed diabetes was found in 11 (12%) patients. Each of the 3 diagnostic approaches used allowed to diagnose patients with non-diagnosed earlier type 2 diabetes mellitus and there were no statistically significant differences in the prevalence of earlier non-diagnosed diabetes depending on the method of diagnostics used, p>0.05. Prediabetes was diagnosed much more frequently – in 47 (53%) patients while measuring glycated hemoglobin, in 43 (48%) patients based on fasting plasma glucose levels and in 28 (31%) patients according to elevated plasma glucose levels 2 hours after taking glucose. Conclusions. Our data revealed high prevalence of earlier non-diagnosed type 2 diabetes mellitus and prediabetes in patients with ischemic heart disease. The measurement of fasting plasma glucose, glycated hemoglobin and oral glucose tolerance test contribute each other in diagnostics of diabetes and prediabetes in the majority of cases.
Other Latest Articles
- Khaniukov O.O., Vasylieva L.I., Yehudina Ye.D., Kalashnykova O.S
- Changes of the level of galectin-3, β-2-microglobulin, albuminuria and end glycation products in patients with chronic heart failure and atrial fibrillation under the influence of treatment
- Analysis of the level of expression of pancytokeratins in epithelial and granulocellular tumors of the ovaries
- Squamous cell carcinoma of unknown primary localization: isolated lesion of cervical lymph nodes
- Neurochemical and behavioral processes in gerontogenesis in conditions of experimental hyperglycemia
Last modified: 2018-07-18 17:05:53