Combinatorial Efficacy of Quercitin and Nanoliposomal Ceramide for Acute Myeloid Leukemia

Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy with limited treatment options. Inflammation is often a contributing factor to the development and progression of AML, and related diseases, and can potentiate therapy failure. Previously, we had identified anti- inflammatory roles and anti-AML efficacy for blueberry extracts. The present study extended these observations to determine that the polyphenols Quercitin inhibited neutral Sphingomyelinase (N-SMase) activity and exerted anti-AML efficacy. Moreover, Quercitin was shown to exert combinatorial antiAML efficacy with Nanoliposomal ceramide. Overall, this demonstrated that Quercitin could block the pro-inflammatory actions of N-SMase and augment the efficacy of antiAML therapeutics, including ceramide-based therapeutics.