Resveratrol derivative-triacetyl-resveratrol interacts directly with the Gli-DNA zinc finger complex

Sonic hedgehog (Shh) pathways have been shown to involve in many cellular processes including cancer cell proliferation and growth. Our studies show that triacetyl-resveratrol (TCRV)interacts with the Gli-DNA zinc finger complex which is a downstream target of Shh pathway. TCRV is a derivative of natural polyphenol compound resveratrol, grape polyphenol with cancer preventative activities in several cancers. TCRV interacted actively and specifically with Gli-DNA zinc finger complex through binding at the site targeted by the affinity (-8.0 Kcal/mol) with the VAL159, ARG162, HIS170, LEU184, GLU185, ASN186, DA14 AND DA15 residues. These studies could be helpful to understand the mechanism of TCRV and its chemo-therapeutic effects for the prevention and treatment of cancers.