MIR-378 TARGET GENE TGFB2 IN THE STAGE II COLON CANCER TISSUE

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. The sensitivity of markers used in the early and painless diagnosis of various cancers, including CRC, remains low. Recent studies have shown that non-protein coding small RNA molecules, called microRNAs (miRNA), play a key role in the mechanism of both the development of cancer and its treatment. In the development of certain types of cancer, including CRC, miRNAs have tumor suppressing and oncogenic effects. Therefore, the aim of the present study was to determine the oncogenic and tumor suppressing miRNAs profiles affecting cancer development and miRNA target gene in the tumor tissue as well as in normal tissues of patients with Stage II CRC. This study array analysis have demonstrated been for the first time in colorectal tumor tissues, 6 of the 8 miRNAs of the miR-378 family (hsa-miR-378i, hsa-miR-378c, hsa-miR-378d, hsa-miR-378e, hsa-miR-378f and hsa-miR-378g) showed that targets TGFB2. As a result; it is possible that early diagnosis of mir-378 colon cancer may have an important role in early diagnosis by investigating expression with TGFB2.