MARKERS LEVEL OF ENDOTHELIAL DYSFUNCTION (ENDOTELIN-1 AND NITROGEN OXIDE) IN BLOOD SYROVISTS AND ALBUMINURIA IN CHILDREN WITH ERYTHROCYTURIA
Journal: Ukrainian Journal of Nephrology and Dialysis (Vol.3, No. 55)Publication Date: 2017-09-04
Authors : V. Minakova;
Page : 49-54
Keywords : erythrocyturia; endothelial dysfunction; endothelin; nitric oxide; albuminuria; children;
Abstract
The aim of our study was to investigate the levels of endothelin-1 and aside nitrogen in the serum of children with kidney diseases that clinically present with hematuria syndrome. Materials and methods: a total of 158 children aged 1 to 18 years with kidney disease, having a course with hematuria. Patients were divided into 3 groups: group 1 – glomerulonephritis; group 2 – hereditary nephritis; group 3 – dismetabolic nephropathy. It was studied the level of endothelin, nitric oxide in serum, the level of hematuria, AU in urine, blood biochemistry, glomerular filtration. Results: the highest level of ET-1 was detected in patients with glomerulonephritis - 0,82±0.055 fmol/ml, with the variation range from 0.10 to 3.2 fmol/ml, which twice exceeded the mean values in the control group, whereas the growth rate of hereditary nephritis and DN was more moderate (0,64±0,063 and 0,54±0,072 fmol/ml, respectively). The NO level increased significantly in patients with glomerulonephritis to 120,2±12,3 μmol/l. Conclusions. Determining the level of ET-1 and NO in the serum of children with kidney diseases, having a course with hematuria, gives the opportunity to get an idea about the presence of endothelium dysfunction. Indicators of endothelial dysfunction can be used as markers of severity and progression of the disease.
Other Latest Articles
- THE EFFECTIVENESS OF THE IMPLEMENTATION OF PROTOCOLS NEPHROLOGY MEDICAL CARE TO CHILDREN AT REGIONAL LEVEL
- PATHOMORPHOLOGICAL CHANGES IN RENAL PARENCHYMA, AFTER MODELING OF ACUTE PYELONEPHRITIS IN MICE, DEPENDING ON THE ABILITY OF BACTERIA TO FORM BIOFILMS
- THE MODERN VIEWS TO DIAGNOSIS OF KIDNEY DAMAGE IN PATIENTS WITH ARTERIAL HYPERTENSION FOR EARLY PREVENTION
- PSYCHOSOMATIC DISORDERS IN PATIENTS WITH CHRONIC KIDNEY DISEASE
- The evaluation of residual kidney function in patients with ckd vd and approaches of its preservation
Last modified: 2018-07-31 20:19:04