Lack of association between CD45 C77G polymorphism and multiple sclerosis in Kashmir
Journal: International Journal of Trend in Scientific Research and Development (Vol.1, No. 6)Publication Date: 2018-07-31
Authors : Insha Zahoor Amrina Shafi Mudasir A Mir;
Page : 1333-1337
Keywords : MS; genetics; CD45; C77G; polymorphism; Kashmir;
Abstract
Multiple sclerosis (MS) is a severe disabling and demyelinating disease of the nervous system. Its etiology involves profound genetic component. The latest contender known to have been correlated with MS is protein tyrosine phosphatase receptor-type C (PTPRC or CD45); however, to date its role remains contentious. The aim of the current study was to examine the association of functionally significant exon 4 C77G polymorphism of CD45 with MS in Kashmiri population from Indian subcontinent. The preliminary findings of our study revealed absence of C77G in majority of the cases as well as controls. These findings strongly suggest that the alterations in CD45 are sporadically associated with the genesis of MS. In conclusion, results from our study are in accordance with some of the international studies; however, more studies with large datasets from Kashmir as well as other ethnic populations are warranted to validate the above preliminary findings and demonstrate the role of CD45 C77G polymorphism in MS pathogenesis. Insha Zahoor | Amrina Shafi | Mudasir A Mir"Lack of association between CD45 C77G polymorphism and multiple sclerosis in Kashmir" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-6 , October 2017, URL: http://www.ijtsrd.com/papers/ijtsrd5813.pdf http://www.ijtsrd.com/biological-science/biotechnology/5813/lack-of-association-between-cd45-c77g-polymorphism-and--multiple-sclerosis-in-kashmir/insha-zahoor
Other Latest Articles
- Isolation, Characterization and Bioactivities of Sambucus wightiana derived Dotriacontanoic acid
- Real Time Intrusion Detection System Using Computational Intelligence and Neural Network: A Review
- Improving Analog Performance and Suppression of Subthreshold Swing using Hetero-Junction Less Double Gate Tunnel FETs
- Hydromagnetic Flow of Nanofluids over a Nonlinear Shrinking Surface with Heat Flux and Mass Flux
- A Novel Design of a 4 Bit Reversible ALU using Kogge-Stone Adder
Last modified: 2018-07-31 21:28:29