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Synthesis, Spectral Analysis, DFT and Antimicrobial of Some Novel Benzimidazole Derivatives

Journal: International Journal of Trend in Scientific Research and Development (Vol.2, No. 4)

Publication Date:

Authors : ;

Page : 2256-2258

Keywords : 2-chloromethyl-1H-benzimidazole; 2-(2-chlorophenyl)-1H-benzo[d]imidazole; 1H-1; 2; 4-triazol-3-amine; IR & NMR spectral data; DFT and Antimicrobial efficiency;

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Abstract

Two novel 2-substituted benzimidazole derivatives were synthesized from 2-chloromethyl-1H-benzimidazole and 2-(2-chlorophenyl)-1H-benzo[d] imidazole with 1H-1,2,4-triazol-3-amine. Their structures were characterized by Infrared spectroscopy, Nuclear magnetic resonance, (1H, 13C), Elemental analysis. Density functional theory (DFT) studies were performed using the B3LYP/6-31G (d, p) basis set to expand imminent into their structural properties. All the synthesized compounds were screened for antimicrobial activity against a panel of selected bacterial and fungal strains using ciprofloxacin and fluconazole as standards. C. M. Mahalakshmi"Synthesis, Spectral Analysis, DFT and Antimicrobial of Some Novel Benzimidazole Derivatives" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-4 , June 2018, URL: http://www.ijtsrd.com/papers/ijtsrd14595.pdf http://www.ijtsrd.com/chemistry/other/14595/synthesis-spectral-analysis-dft-and-antimicrobial-of-some-novel-benzimidazole-derivatives/c-m-mahalakshmi

Last modified: 2018-08-02 16:01:54