KIDNEY DAMAGE IN CHILDREN WITH SEVERE ACUTE INTESTINAL INFECTIONS

Introduction. Acute intestinal infections and diarrhea-associated hemolytic-uremic syndrome (HUS) are the main cause of acute renal failure in children. Objective: to establish the frequency of development of acute renal failure in children hospitalized in the intensive care unit of an infectious hospital with severe forms of acute intestinal infections. Material and methods. A retrospective comparative statistical analysis of 123 case histories of children with acute intestinal infections who were undergoing treatment in the intensive care unit of the Grodno Regional Infectious Disease Clinical Hospital was conducted. Patients were divided into 3 groups: 1 group (n = 84) - children with acute intestinal infections and lack of clinical and laboratory signs of impaired renal function; 2 group (n = 27) - children with acute intestinal infections and prerenal acute renal failure (reduced diuresis, increased urea and / or serum creatinine, normalized against the background of ongoing rehydration therapy during the day); 3 group (n = 12) - children with acute intestinal infections and renal acute renal failure. Results. The age of the children was 1.0 (0.2, 2.2) year. Children prevailed up to a year – 49,6%, from one to five years – 42,3%, over 8 years – 8,1%. Oligouria was recorded in 28.5% of children, anuria in 3.3%. A statistically significant difference in levels of urea and creatinine in groups (p˂0,05) was established. The highest rates were observed in patients of the 3 group. In 9 of them (75%), a typical HUS associated with infectious diarrhea was diagnosed. Conclusion. In 21,9% of children with acute intestinal infections, prerenal acute renal failure was diagnosed, in 9,8% - renal. The main cause of renal acute renal failure in children with severe forms of acute intestinal infections is a typical HUS associated with the infectious etiology of diarrhea.