Influence of Vitamin D Receptor Gene Polymorphism on Expressiveness of Osteopenic Syndrome in Patients with Chronic Pancreatitis Accompanied with Hypertensive Disease

Research results of the effect of vitamin D receptor gene polymorphism on the formation of osteopenic syndrome in the isolated course of chronic pancreatitis (CP) and its combination with hypertensive disease (HD) are presented in the present study. Materials and methods. 110 patients were enrolled in the study. 70 of these people were included in the main group with a combined course of CP and HD; the average age of the group was 33.2 ± 2.1. The comparison group consisted of 40 patients with isolated HP; their age was 32.9 ± 3.1. The duration of HP was from 2 to 15 years with an interquartile magnitude (IM) of 4-7 years, with a medial tendency of 5 years. The history of HD ranged from 3 to 17 years with the same IM (4-8 years) and the medial trend of 5 years. The benchmarks for biochemical and genetic studies were obtained in a study of 70 practically healthy individuals, representing the main group by age and sex. HD diagnosis was performed on the recommendations of the European Society for Arterial Hypertension (ESAH) (2009) and the recommendations of the Working Group on Arterial Hypertension of the Ukrainian Association of Cardiology for the prevention and treatment of hypertension (2012), taking into account the classification of the degree and stage of hypertension, the risk of hypertension (risk stratification for evaluation forecast AG). The diagnosis of HD was verified by evaluating patients' complaints, anamneses, results of clinical and laboratory and instrumental research methods, referring to the Ministry of Health of Ukraine order № 271 dated 13.06.2005, updated on 09.10.2014 order № 638. Results and discussion. The selected gene refers to candidate genes whose polymorphism is associated with the development of osteopenic states. It was found that the presence of the pathological genotype BB of the VDR gene is a predictor of the development of osseous lesion, which is confirmed by the presence of a significant number of fractures (32,8%) щт the background of osteopenic conditions in patients with CP and HD in comparison with patients with isolated CP (25 %) This circumstance can be a result of the total quantitative (by the pathological genotype of BB) and qualitative (combination of calcium-dependent diseases) "accumulation", which causes the correction of dietary recommendations and is followed by the appointment of prophylactic courses of therapy with calcium preparations. Conclusions. The course of chronic pancreatitis in young people in 10% of cases is accompanied by fractures of bones of different localization. Joining the CP and HD significantly increases the number of such individuals, which may be the result of changes in calcium metabolism rates occurring in calcium-dependent diseases like chronic pancreatitis and hypertension. The presence of osteoporosis changes in patients with comorbidity of CP and HD may be due to the polymorphism of the vitamin D receptor gene, with the predominance of B-alleles.