Absorption of Water and Electrolytes from a Liposome Based Oral Rehydration Solution: An in vivo Perfusion Study on Mucosal Injured Small Intestine Rat Model

In the present study, rats were used to identify the efficacy of three types of Oral Rehydration Solutions (ORSs); standard ORS (S-ORS), hydrolyzed starch ORS (HS-ORS) and Liposomal ORS (Lipo-ORS) using an in vivo perfusion technique on a 5-Fluorouracil mediated mucosal injured rat small intestine model. This study comparess the absorption of electrolytes (Na+, K+, Cl-) and water from these three types of ORSs and compared among these substances from each other. It was found that liposome based ORS is associated with significantly higher Na+, K+, Cl- and water absorption compared to hydrolyzed starch ORS or standard ORS. It can be concluded that liposomes enhance more electrolyte absorption from a carbohydrate electrolytes solution in mucosal injured small intestine of rat than normal small intestine of rats. These findings underscore the potential clinical importance of liposome based electrolyte solution for rehydration.