Propolis Hepatoprotector Effect on Liver Damage of White Mice Induced by Valproic Acid

Propolis is a natural product that has a high antioxidant, namely Caffeic Acid Phenyl Ester (CAPE). CAPE has antioxidant activity 4-6 times stronger against oxidants, hydrogen peroxide, and free radicals, compared to vitamin C and N-acetylcysteine. Antioxidants are known to be hepatoprotective. This study aims to determine the effect of propolis on the activity of Serum Glutamic Pyruvic Transaminase (SGPT) and histological features of valproic acid-induced mouse liver. The experimental animals used were 24 mice divided into 4 groups randomly; group 1 was given distilled water, group 2 was given valproic acid dose 350 mg/kg body weight as an induction of liver damage, group 3 was given propolis dose 280 mg/kg body weight, and group 4 was given a dose of 560 mg/kg BB. Valproic acid-induced mice showed liver damage characterized by an increase in the average activity of SGPT, liver cell degeneration scores, and inflammatory cell (inflammation) scores. Provision of propolis dose 280 mg/kg body weight and 560 mg/kg body weight can reduce the average activity of SGPT, liver cell degeneration score and inflammatory score in liver cells. These results indicate that propolis with a dose of 280 mg/kg body weight and 560 mg/kg body weight gives a hepatoprotective effect. Propolis dose 280 mg/kg body weight is the best dose and is more effectively used as a hepatoprotective agent.