ANTIBACTERIAL PROPERTIES OF NEW CHITOSAN-BASED SCHIFF BASES

Chitosan, a derivative of chitin, one of the most widespread natural polysaccharides, is of great interest in terms of practical application. The importance of this polymer and its derivatives cannot be overestimated since it is currently used in such spheres of human activity as medicine, agriculture, food and textile industries, nuclear medicine, pharmaceutics and cosmetology, ecology and others. Its antibacterial properties are of particular interest. In the A.I. Alikhanyan National Science Laboratory Foundation (Yerevan Physics Institute) the works are being conducted on obtaining/synthesizing new samples of chitosan Schiff bases. The present work is devoted to the study of the antibacterial activity of newly synthesized Schiff bases derivatives of chitosan. As test cultures in studying their antibacterial properties, several aerobic gram-negative and one gram-positive bacteria were used. It has been reliably shown that at least a two of the five samples of chitosan and its derivatives studied by us had pronounced antibacterial properties. The effectiveness of the preparations impact differed from culture to culture. Of all the cultures tested, the wild type of the bacterial culture of Bacillus cereus proved to be the most sensitive. The term ?effective ratio? (ER) is proposed for the shift of selected ratios one way or another, which resulted either in a complete stop of cell proliferation or cessation of the chitosan derivative to affect the ability of cells to reproduce.